crofab for south american rattlesnakes - Experts Forum at VenomousReptiles.org

crofab for south american rattlesnakes	Reply
by thenewdisciple on September 5, 2005	Mail this to a friend!
is crofab effective against south american rattlesnakes?

RE: crofab for south american rattlesnakes	Reply
by Phobos on September 5, 2005	Mail this to a friend!
Let me put it this way, IT'S ALMOST EFFECTIVE FOR NORTH AMERICAN CROTALIDS. Need I say more? Al

RE: crofab for south american rattlesnakes	Reply
by Rabies on September 5, 2005	Mail this to a friend!
At a guess there might be some cross effectiveness but I doubt much. The main action the venom has on humans in S. America is on the neuromuscular junction and the skeletal muscle. John

RE: crofab for south american rattlesnakes	Reply
by tj on September 6, 2005	Mail this to a friend!
Not effective, durissus is not one of the species used to make Cro-Fab. Costa Rican Poly, Bioclon Antivipmyn, and Instituto Butantan AV's are effective against durissus. There are a few other, as well. I've read that Wyeth crotalid poly can be used for certain durissus, but I'm not quite sure about that one.

RE: crofab for south american rattlesnakes	Reply
by Phobos on September 6, 2005	Mail this to a friend!
Tj: From the Wyeth Circular for the A/V. As you can see it's a much better product as far as being able to neutralize many more species. Remember it's a "Whole Gobilin" serum and is much more capable of causing allergic reactions. COMPOSITION Antivenin (Crotalidae) Polyvalent, Wyeth, is a refined and concentrated preparation of serum globulins obtained by fractionating blood from healthy horses immunized with the following venoms: Crotalus adamanteus (Eastern diamond rattlesnake), C. atrox (Western diamond rattlesnake), C. durissus terrificus (tropical rattlesnake, Cascabel), and Bothrops atrox (“Fer-delance’’). Antivenin (Crotalidae) Polyvalent, Wyeth (hereinafter referred to as Antivenin) contains protective substances capable of neutralizing the toxic effects of venoms of crotalids (pit vipers) native to North, Central, and South America, including rattlesnakes (Crotalus, Sistrurus); copperhead and cottonmouth moccasins (Agkistrodon), including A. halys of Korea and Japan; the Fer-de-lance and other species of Bothrops; the tropical rattler (Crotalus durissus and similar species); the Cantil (A. bilineatus); and bushmaster (Lachesis mutus) of South and Central America. Al

RE: crofab for south american rattlesnakes	Reply
by tj on September 6, 2005	Mail this to a friend!
That covers alot of ground. Thanks for the info. Are you and Matt making any progress with Costa Rican Poly, or are they still having difficulties? Or are you getting something similar? -TJP

RE: crofab for south american rattlesnakes	Reply
by MattHarris on September 6, 2005	Mail this to a friend!
its still a slow process. I've contacted them several times, but have gotten no response. I may have to go through a C.R. serpentarium to get it....which doesn't leave me much hope for getting it for the A/V bank. MCH

RE: crofab for south american rattlesnakes	Reply
by Rabies on September 7, 2005	Mail this to a friend!
I'm aware of the fact that durissus is not one of the species used for CroFab, neither is Helleri but it works effectively if given early enough. There's most probably some components in the antivenom thats capable of nuteralizing minor elements in the venom of Central and South American rattlers in a laboratory setting(my fault for not taking the time to type my answer correctly) but totaly useless in the bitten victim, as you pointed out. John

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