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Effects of anti-venom on necrosis?
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by FLAohHerper on May 3, 2009
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This is a topic that had arose lately for me and was wondering if there had been any further findings.When receiving anti-venom,will it have a true effect on localized tissue damage(necrosis)? Or does the severity of necrosis depend on immediate care of the bite site over time? Or is there still no factual findings either way? A friend of mine had recently been bitten by a moc and received 12 vials...and had lost his finger in the end.I remember I had heard Sean Bush stating that there is no evidence that shows anti-venom prevents or stops progression of necrosis in the bite area(I can't rememeber the exact quote or show,but it was something of that nature).Anyone with imput or experiences that could shed light on this situation?
Thanks
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RE: Effects of anti-venom on necrosis?
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by Jahon on May 3, 2009
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Dr. Bush had stated that antivenom cannot reverse damage that has already been done but can prevent further damage. "Time is tissue," as he says. As in get antivenom as fast as possible to prevent further tissue damage that may have already been done. Hope that helps.
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RE: Effects of anti-venom on necrosis?
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by Crotalusssp on May 4, 2009
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Antivenin attaches to and blocks the venom on a molecular level by binding to the enzymes thus preventing them from attaching elsewhere. Because of this the antivenin can only attach to free enzymes. Once the enzymes have bound to and begun tissue destruction for example, this can not be undone only possible prevention from additional tissue damage by free venom.
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RE: Effects of anti-venom on necrosis?
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by FLAohHerper on May 4, 2009
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So the question is,how long does it take the venom to bind to tissues and begin destruction?Or I guess there are many factors in that to answer accurately?
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RE: Effects of anti-venom on necrosis?
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by Crotalusssp on May 4, 2009
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Venom is composed of MANY different components. An enzyme component would begin it mechanism for destruction upon binding to its particular specific site. This may take as little as a minute, maybe even less.
Charles
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