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allergies, anaphylactic shock
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by asud on October 7, 2009
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Regarding adverse responses to antiserum:
a.) I gather that sheep derived av results in less allergic reactions than horse av. Is this a fair statement?
b.) Are sheep becoming more prevalent as a source for av (or is it exclusively used for pit viper av's?) When sheep sub in for horses, is this decision related more to reducing allergic reactions or is just cost of upkeep, etc.?
c.) I know it's not black and white, but in general does proper medical protocol dictate that a bite victim get a minor dose of av to determine allergy?
d.) Lastly, what does one do in case a victim is KNOWN to be allergic to antibodies? Do you just administer it anyway? Any difference in approach--whether or not to use on known allergic people--when it's an elapid as opposed to, say, a crotalid or viper?
Thank you for any insights, Adam
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RE: allergies, anaphylactic shock
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by agkistrodude on October 7, 2009
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Adam, I'll take a WAG at it.(Wild assed guess)
A. yes
B. Sheep do cause far less allergic reactions, and its cheaper to keep a herd of sheep than a herd of horses. So I would say both come into play.
C. I believe there is a test to determine if the patient will be allergic, at least with the old Wyeth there was. I don't recall being tested for allergic reaction to Cro-fab though.(although I may have been, I was in pretty bad shape at the time)
D. I would think that would depend on the case. If someone that's known to be allergic is in very bad shape, I would think they give the anti-venom and at the same time prepare for allergic reaction, or take preventive measures.(if I'm not mistaken, I believe this happened on one of the "Venom ER" episodes) Or if the patient isn't looking like they took a real bad bite, maybe they hold off on the anti-venom.
By no means am I saying this is what happens, I'm NOT a medical professional and I didn't even stay at a Holiday Inn Express last night. Just my thoughts through some research and a little personal experience.I'd be interested in what some others in the medical field say. Maybe CHarper can get a few minutes to chime in with his expertise although I'm not sure how often he gets to check this site in Iraq. Take care, Marty
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RE: allergies, anaphylactic shock
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by pictigaster1 on October 7, 2009
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I am allergic to horse serum How do I know anaphylactic shock and a near death reaction from wyth poly.Took crofab fine years later.
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RE: allergies, anaphylactic shock
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by Nakita on October 7, 2009
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I can add what my personal physician has told me.
I have a relatively rare disease called Mastocytosis that makes me exceptionally predisposed to anaphylactic shock. When I spoke to my physician regarding the possibilities of a bite he stated that if the bite was severe enough to warrant serum (if I didn't already experience anaphylaxis from the bite itself)then they would administer a large dose of IV antihistamine and be ready to intubate and administer Epinephrine.
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RE: allergies, anaphylactic shock
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by BobH on October 7, 2009
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Adam, it is my understanding that crofab is produced in only one sheep colony in the outback of Australia because it is the only one certified prion free! Prions cause some strange diseases; mad cow disease is just one of them. If this is incorrect, please let me know.
Bob
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RE: allergies, anaphylactic shock
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by pictigaster1 on October 7, 2009
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Hay Bob I was reading about prions.Is it true that they are a malformed protein .Is it true that by all purpose they are dead and given the chance show just the opposite .
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RE: allergies, anaphylactic shock
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by Cro on October 7, 2009
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Bob is right about the dangers of Prion disease in various animals.
In Cows it is called Mad Cow Disease, or BSE, and in Sheep and Goats it is called Scrapie Disease, and in Deer it is called Chronic Wasting Disease, and in Trout, it is called Whirling disease, and in humans it is called Creutzfeldt-Jakob Disease, or Kuru.
When vaccines are made from animal tissues, there is a great chance that the Prion Disease can spread. Not too many years ago, thousands of kids of short stature or dwarf size were given injections of Human Growth Hormone, to help them grow to normal size.
The unfortunate thing, was the vaccine was made from the pituitary gland from human cadavers, and some of those dead humans had died of Prion Disease, and that disease was spread to the kids. Most of those kids are now dead or dying from Creutzfeldt=Jakob Disease.
There is also a lot of evidence that many of the old folks now dying of Alzheimer's Disease are actually dying of CJD. The morgues refuse to do autopsies, because if they do, and the person does have CJD, then all of the operating instruments are contaminated, and Prions are not killed by normal autoclave sterilization.
Also, there is plenty of evidende that BSE can be transmitted through milk, cheese, and even veggies that were grown with manure.
Not long ago, about a hundred folks here in GA who had brain surgery at Emory were informed to come in, as it had been found that a brain surgery patient had CJD, and all of the subsequent folks who the same instruments were used on were exposed. Many of those folks will eventually have CJD.
Prion disease is a really fascinating subject, that everyone should become familiar with. Especially in this country where downer cows are routinely ground up with thousands of other cows, and made into hamburger that goes out to thousands of folks.
But, I an rambling on a bit much on one of my favorite subjects. Getting back to the antivenin production, we might avoid the dangers of Prions in the production of antivenin, if more work was done in producing antivenins in chicken eggs, or, perhaps using bacteria, algae, or molds to grow the vaccine on.
Anyway, read these if you want a reason to stop going to fast food hamburger places.
MAD COWBOY: Plain Truth from the Cattle Rancher Who Won't Eat Meat
Animal Pharm: One Man’s Struggle to Discover the Truth about Mad Cow Disease and Variant CJD
Best Regards
John Z
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